Melanie Macherey and Markus Schwarz attended this year's conference of the Society of Environmental Toxicology and Chemistry (SETAC) Europe in Helsinki (26-30 May). Again this year, endocrine disruption was an important issue, also on account of the new "ECHA/EFSA Guidance for the identiﬁcation of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009", published in June 2018. In order to meet the requirements of the Guidance, concepts were discussed and new scientific methods were presented, e.g. for modelling population-relevant adverse effects in non-target organisms or for identifying endocrine disruption of thyroid hormone signaling. There was also a lively discussion as to whether - in view of a hazard-based assessment in the EU - biological plausibility alone is sufficient, or whether the causality of the link is decisive if an adverse effect is to be assigned to a specific endocrine mechanism of action; and what role the mechanistic potency of a substance plays for this mechanism of action.