Dose-response modelling (or benchmark dose modelling) is a key method for deriving health-based guidance values in a scientifically rigorous manner. Recently, an expert meeting took place in Geneva at WHO headquarters in order to facilitate the update of Chapter 5 (Dose-Response Assessment and Derivation of Health-Based Guidance Values) of the Environmental Health Criteria document 240: “Principles and methods for the risk assessment of chemicals in food”. Klaus Schneider took part as an invited expert. The updated chapter 5 is expected to be published in 2019.

The legally effective occupational exposure limit values (OELs) for the evaluation of hydrocarbon mixtures in Germany using the RCP methodology are published in the Joint Ministerial Gazette (GMBl, date: 30.11.2017). FoBiG carried out the revision and based on this work commented on the publication by McKee and colleagues "The reciprocal calculation procedure for occupational exposure limits for hydrocarbon solvents: an update" and compared them with the standards in force in Germany. The letter to the Editor is published here.

vSubstance evaluations for their potential endocrine-disrupting (ED) properties are an integral part of the approval process for biocides and pesticides. For these regulatory areas legally binding criteria for the ED assessment have been established. The evaluation is supported by the EFSA / ECHA Guidance for the identification of endocrine disruptors. Criteria for ED substance evaluation under REACH have not yet been adopted. However, a rating as an endocrine disruptor also has far-reaching consequences under REACH. FoBiG will gladly assist you in assessing your substances for a possible ED effect.

For further questions please contact Ulrike Schuhmacher-Wolz.

FoBiG continues its successful work on draft dossiers for harmonized classification and labelling on behalf of DG Environment in a new project. In this project FoBiG will prepare four draft CLH dossiers with proposals for CMR properties and five draft dossiers on harmonized classification for acute toxicity. Results will be discussed with ECHA and the relevant Member States Competent authorities.

For further information please contact Klaus Schneider.

An exciting year, with a lot of changes for FoBiG, comes to an end. Our veterans Fritz Kalberlah and Martin Hassauer retired as company partners and staff members – and support us further as freelancers at their whim. FoBiG won over four long-time staff members as new company partners and with our new colleagues Melanie Macherey und Marco Dilger our scientific team got substantial reinforcement. We are prepared for the future!

Many thanks to all friends, colleagues and clients for their good cooperation. We wish you a well-deserved break, a relaxing Christmas holiday and a Happy New Year!

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