Assessment of Perfluorinated Carbonic and Sulfonic Acids

Perfluorinated chemicals (PFC) are highly persistent and mobile in the environment. Foods are appreciably polluted with PFC, especially fish. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are the most prominent and well-studied representatives, which have been already evaluated by several organizations (e.g. European Food Safety Authority). FoBiG has derived guide values for oral exposure for 11 PFC and 4 only partially fluorinated derivatives, under consideration of a) endpoints with species specific mechanisms b) differences in elimination kinetics used for interspecies extrapolation and c) a pragmatic approach to consider combined effects at co-exposure. The assessment, for example, includes perfluorobutanoic-, -pentanoic-, … to decanoid acid; perfluorobutane, -hexane- and -octanesulfonic acid; 1H,1H,2H,2H-perfluorooctanssulfonic acid, 2H,2H-perfluordecanoic acid (report unpublished).

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